(For more market insights, including options activity, click on ; for the Day Ahead newsletter link.reuters.com/mex49s; for the Morning News Call newsletter, link.reuters.com/nex49s) U.S. stocks opened little changed on Wednesday, with the S&P 500 near its record high reached in the prior session, after data on the labor market was slightly below expectations. Dow Jones industrial average futures were down 0.09 percent at 16,435, S&P 500 futures were up 0.11 percent at 1,879.9 and Nasdaq 100 futures were up 0.49 percent at 3,668.
** MANNKIND CORP, $7.2, +79.10 pct
U.S. health advisers on Tuesday recommended approval of the company's inhaled diabetes drug, and said the experimental treatment could help some patients, especially those wary of needles typically used with traditional insulin therapy.
** ENVIVIO INC, $4, +21.21 pct
The company, which provides video processing and delivery software, said its encoders are powering live high-definition sports channels on Apple Inc's Apple TV for a major European service provider.
** APOLLO EDUCATION GROUP, $32.6, -7.28 pct
The company reported lower-than-expected quarterly revenue as enrollments declined 16.8 percent at its flagship University of Phoenix.
The company also said it had received a subpoena from the U.S. Department of Education's Office of Inspector General, seeking information about the operations of the Northeast region of the University of Phoenix.
** DFC GLOBAL CORP, $9.4, +4.68 pct
The pawn and payday lender said it would sell itself to private equity firm Lone Star Funds for $9.50 per share in cash, or about $1.3 billion, including debt.
** GLAXOSMITHKLINE PLC, $53.03, -0.51 pct
** AGENUS INC, $3.025, -8.61 pct
GlaxoSmithKline has stopped a high-profile clinical trial using a novel vaccine to fight lung cancer after deciding it will not be possible to find a sub-group of patients who might benefit.
Agenus contributed technology to the treatment, the MAGE-A3 vaccine, which is aimed at people with established disease, helping their immune systems to prevent the recurrence of disease post surgery.
** AGRIUM INC, $93.99, -3.62 pct
The Canadian fertilizer company said on Wednesday a late start to spring and railroad-related backlogs had hurt its first-quarter earnings.
** KERYX BIOPHARMACEUTICALS INC, $17.0299, +1.49 pct
The drug developer said the European Medicines Agency validated the company's marketing approval application for its experimental drug Zerenex as a treatment for hyperphosphatemia, an abnormally high concentration of phosphates, in patients with chronic kidney disease.
The validation confirms that the submission is sufficiently complete for the regulator to begin the formal review process, Keryx said.
** COGNIZANT TECHNOLOGY SOLUTIONS CORP, $52.78, +2.15 pct
UBS upgraded the IT service provider's stock to "buy" from "neutral", according to theflyonthewall.com.
** INTUITIVE SURGICAL INC, $503.01, +1.91 pct
JMP Securities analyst J T Haresco raised his rating on the company's stock to "market outperform" from "market underperform", saying that the company's newly approved surgical robot system would eventually replace a large percentage of the older version in use in the United States and could accelerate revenue growth in 2015.
The company said on Tuesday the U.S. Food and Drug Administration approved for marketing an upgraded version of its flagship robotic surgical system.
** MONSANTO CO, $113.06, -0.44 pct
The world's largest seed company reported higher-than-expected quarterly earnings on Wednesday as its corn and soybean businesses expanded globally.
** GENCO SHIPPING & TRADING LTD, $1.65, +2.48 pct
The dry bulk shipper said it entered into agreement with lenders to extend the expiration of the forbearances and waivers under the relief agreements to April 21.
** STRATASYS LTD, $111.9, +0.84 pct
The 3D printer maker said it agreed to buy two privately held providers of additive manufacturing services providers - Solid Concepts Inc for $295 million and Harvest Technologies for an undisclosed amount.
Stratasys said the deals are expected to add to adjusted earnings per share within the first 12 months after closing.
** NORDIC AMERICAN TANKERS LTD, $9.92, +0.92 pct
The tanker company almost doubled its quarterly cash dividend to 23 cents per share from 12 cents per share. The company will also pay dividend of 13 cents per share in stock of Nordic American Offshore Ltd to shareholders with Nordic American Tankers shares above a certain threshold.