'Intelligent' surgical knife can sniff out cancer tissue

Wed Jul 17, 2013 2:24pm EDT
 
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By Ben Hirschler

LONDON (Reuters) - Scientists have created an "intelligent" surgical knife that can detect in seconds whether tissue being cut is cancerous, promising more effective and accurate surgery in future.

The device, built by researchers at London's Imperial College, could allow doctors to cut back on additional operations to remove further pieces of cancerous tumors.

The technology, effectively merging an electrosurgical knife that cuts through tissue using heat with a mass spectrometer for chemical analysis, has also been shown to be able to distinguish beef from horsemeat.

Surgeons often find it impossible to tell by sight where tumors end and healthy tissue begins, so some cancer cells are often left behind. A fifth of breast cancer patients who have lumpectomy surgery need a second operation.

The new "iKnife" is designed to get round the problem by instantly sampling the smoke given off as tissue is cut through using an electric current to see if it is cancerous.

In the first study to test the device in patients, the iKnife diagnosed tissue samples from 91 patients with 100 percent accuracy, researchers at Imperial College London reported in Science Translational Medicine on Wednesday.

Currently, removed tissue can be sent for laboratory analysis while the patient remains under general anesthetic - but each test takes around half an hour, while the iKnife provides feedback in less than three seconds.

It does this by analyzing biological information given off from burning tissue and comparing the findings to a database of biological fingerprints from tumors and healthy tissue.   Continued...

 
Julia Balog of Imperial College London demonstrates the Intelligent Knife on a piece of meat at St Mary's Hospital in London July 17, 2013. REUTERS/Luke MacGregor