Factbox: Breakthrough Prize laureates

Mon Nov 10, 2014 11:39am EST
 
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MOUNTAIN VIEW CALIF. (Reuters) - Here are the Breakthrough Prize winners for 2014:

LIFE SCIENCES

- C. David Allis of the Rockefeller University for the discovery of covalent modifications of histone proteins and their critical roles in the regulation of gene expression and chromatin organization, advancing our understanding of diseases ranging from birth defects to cancer.

- Alim Louis Benabid of Joseph Fourier University for the discovery and pioneering work on the development of high-frequency deep brain stimulation (DBS), which has revolutionized the treatment of Parkinson's disease.

- Emmanuelle Charpentier of Helmholtz Center for Infection Research and Umea University for harnessing an ancient mechanism of bacterial immunity into a powerful and general technology for editing genomes, with wide-ranging implications across biology and medicine.

- Jennifer A. Doudna of the University of California, Berkeley, Howard Hughes Medical Institute and Lawrence Berkeley National Laboratory for harnessing an ancient mechanism of bacterial immunity into a powerful and general technology for editing genomes, with wide-ranging implications across biology and medicine.

- Victor Ambros of the University of Massachusetts Medical School for discovering a new world of genetic regulation by microRNAs, a class of tiny RNA molecules that inhibit translation or destabilize complementary mRNA targets.

- Gary Ruvkun of Massachusetts General Hospital and Harvard Medical School for discovering a new world of genetic regulation by microRNAs, a class of tiny RNA molecules that inhibit translation or destabilize complementary mRNA targets.   Continued...