Factbox: Drugs to treat alcoholism, old and new

Wed Feb 24, 2010 8:33pm EST
 
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(Reuters) - Scientists researching drugs to treat alcoholism are building on an established range of treatments which target known areas of brain activity.

The following overview outlines treatments already available, and those more recently launched or in clinical trials, and the brain activity they target.

EXISTING TREATMENTS

The three main drugs with regulator approval for treating alcohol dependence are naltrexone, acamprosate, and disulfiram. A fourth, topiramate, which is used in epilepsy, is showing some encouraging results in clinical trials for alcoholism.

* Naltrexone blocks opioid receptors that are involved in the rewarding effects of drinking and in the craving for alcohol. It reduces relapse to heavy drinking and is highly effective in some but not all patients.

* Acamprosate is an NMDA agonist and is thought to reduce symptoms of protracted withdrawal, such as insomnia, anxiety, restlessness, and dysphoria (an unpleasant or uncomfortable emotional state, such as depression, anxiety, or irritability). It may be more effective in patients with severe dependence.

* Disulfiram interferes with the degradation of alcohol, resulting in the accumulation of acetaldehyde, which, if the patient drinks alcohol produces an unpleasant reaction that includes flushing, nausea, and palpitations. Compliance can be a problem, but among patients who are highly motivated, disulfiram can be very effective.

TREATMENTS UNDER DEVELOPMENT

Launched or Clinical trials phase of development for the treatment of alcoholism   Continued...