(Adds further details on Amgen previously dropping drug)
Sept 1 (Reuters) - Canada’s Valeant Pharmaceuticals International Inc is buying rights to AstraZeneca Plc’s late-stage experimental psoriasis drug brodalumab after it was dropped by Amgen Inc in May.
Amgen pulled out of the project because suicidal thoughts were observed in some patients taking the medicine, casting a shadow over its prospects.
Valeant said on Tuesday it would make an upfront payment of $100 million to AstraZeneca, and additional pre-launch milestone payments of up to $170 million and sales-related milestone payments of up to $175 million following the launch.
Regulatory submissions in the United States and Europe for brodalumab in moderate-to-severe psoriasis are planned for the fourth quarter of 2015.
The arrangement excludes Japan and certain other Asian countries where rights to the drug are held by Kyowa Hakko Kirin Co.
Brodalumab belongs to a class of drugs called IL-17 inhibitors that work by blocking a signaling pathway that plays a key role in inducing and promoting inflammatory diseases. Psoriasis is a chronic autoimmune disease in which the growth cycle of skin cells is accelerated.
AstraZeneca said the deal, which is expected to complete in the fourth quarter of 2015, would not materially impact its financial forecasts for 2015. Income from the upfront and milestone payments will be reported as “externalisation revenue”. (Reporting by Ben Hirschler in London and Supriya Kurane in Bengaluru; Editing by Gopakumar and David Clarke)