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* The Morning News Call newsletter: tmsnrt.rs/2fwPLTh U.S. stock indexes were set to open slightly lower on Tuesday as investors awaited results from big retail names to conclude a largely positive earnings season that has helped power a recent record rally.
At 8:17 ET, Dow e-minis were down 0.09 percent at 22,043. S&P 500 e-minis were down 0.12 percent at 2,474.5, while Nasdaq 100 e-minis were down 0.11 percent at 5,927.5. Drugmakers' hopes for gene therapy rise despite tiny sales in Europe BUZZ-Retail ETF: Attempts to emerge from Amazon's shadow The top three NYSE percentage gainers premarket: ** Twilio, up 14.0 pct at $34.80 ** Michael Kors, up 13.5 pct at $42.25 ** Valeant Pharmaceuticals, up 9.6 pct at $16.85 The top three NYSE percentage losers premarket: ** BioAmber, down 34.4 pct at $0.65 ** PlainsGP Holdings, down 18.7 pct at $21.00 ** Plains All American Pipeline, down 14.3 pct at $21.60 The top three Nasdaq percentage gainers premarket: ** FibroGen, up 60.8 pct at $53.70 ** Esperion Therapeutics, up 17.3 pct at $53.00 ** TerraVia Holdings, up 15.4 pct at $0.06 The top three Nasdaq percentage losers premarket: ** Depomed, down 18.7 pct at $7.50 ** Ekso Bionics, down 10.4 pct at $1.80 ** MannKind Group, down 9.4 pct at $1.06 ** Valeant Pharmaceuticals International Inc: up 9.6 pct at $16.85 premarket UPDATE 1-Valeant cuts revenue forecast; makes progress on debt repayment ** CVS Health Corp: up 0.5 pct at $79.55 premarket UPDATE 1-CVS Health's profit beats on higher demand for pharmacy services ** Michael Kors Holdings Ltd: up 13.5 pct at $42.25 premarket UPDATE 1-Michael Kors lifts revenue forecast, shares soar BUZZ-Forecasts FY revenue above estimates ** FibroGen Inc: up 60.8 pct at $53.70 premarket BUZZ-Soars as lung fibrosis drug succeeds mid-stage study ** Sunrun Inc: down 7.7 pct at $6.85 premarket BUZZ-Shares fall on Q2 miss ** McDonald's Corp: up 0.3 pct at $155.50 premarket McDonald's bumps up estimate for stores in China by 2022 ** Plug Power Inc: down 6.7 pct at $2.22 premarket BUZZ-Trips after results ** Ralph Lauren Corp: up 5.2 pct at $82.25 premarket Ralph Lauren's quarterly sales down 13.2 pct ** Envision Healthcare Corp: up 1.7 pct at $56.00 premarket UPDATE 1-Envision to sell ambulance business to KKR in $2.4 bln deal ** Schlumberger NV: flat at $66.55 premarket BUZZ-Schlumberger working with Libya's Sirte Oil after 3-yr gap ** Tenet Healthcare: down 9.2 pct at $15.16 premarket BUZZ-In the sick bay as lower patient numbers hit results, forecast ** Twilio Inc: up 14.0 pct at $34.80 premarket BUZZ-Surges on strong quarter, raised FY rev forecast ** Avis Budget Group Inc: down 8.4 pct at $30.57 premarket BUZZ-Shares skid on Q2 miss, FY profit view cut ** Endo International Plc: up 6.3 pct at $9.90 premarket UPDATE 1-Generic drugmaker Endo tops estimates, raises revenue forecast BUZZ-Drops on bigger bill to settle mesh product claims ** Depomed Inc: down 18.7 pct at $7.50 premarket BUZZ-Slides on Q2 EPS miss, lower revenue forecast ** LendingClub Corp: up 8.1 pct at $5.90 premarket WRAPUP 1-Online lenders upbeat about turnaround progress, but worries linger BUZZ-Posts smaller Q2 loss (Compiled by Tamara Mathias in Bengaluru; Edited by Maju Samuel)